三级aa视频在线观看-三级国产-三级国产精品一区二区-三级国产三级在线-三级国产在线

Global EditionASIA 中文雙語Fran?ais
China
Home / China / Innovation

Scientists discover microglia in peripheral nervous system, opening new pathways for treating neurological disorders

Xinhua | Updated: 2025-04-08 09:54
Share
Share - WeChat

SHENZHEN -- Chinese scientists have, for the first time, confirmed the existence of microglia in the peripheral nervous system (PNS). This breakthrough provides novel insights into PNS development, opening new pathways for treating neurological diseases such as developmental disorders, nerve injury, abnormal pain and nerve viral infections.

The study, conducted by a research team at the Shenzhen Institutes of Advanced Technology (SIAT) under the Chinese Academy of Sciences (CAS), was published in the latest issue of Cell.

An international reviewer of the study commented: "This is a very important new discovery and frameshift in our understanding. Prior to this, we assumed there were no microglia-like cells outside the CNS (central nervous system)."

Immune cells, an essential part of the immune system, play significant roles in embryonic development, organ formation, maintaining body stability, and influencing disease occurrence and progression. Microglia, a subset of tissue resident immune cells discovered in 1919, have been thought to exist solely within the CNS, scientists explained.

However, a 2023 study of the team led by researcher Li Hanjie, also published in Cell, discovered microglia in human fetal skin, testicle and heart tissues.

"Initially, we observed microglia in non-CNS tissues but could not confirm their presence in the PNS. This uncertainty drove over a year of rigorous investigation," recalled Wu Zhisheng, first author of the latest Cell paper.

The team conducted experiments on diverse unconventional model animals, including humans, monkeys and pigs, collecting biological samples from wild and farmed sources and developing a novel research framework. Their efforts conclusively verified the existence of PNS microglia.

Further analysis of 24 vertebrate species-spanning fish, amphibians, reptiles and mammals-revealed that PNS microglia originated at least 450 million years ago in the common ancestor of bony fish. Notably, larger-bodied species exhibited larger neuronal somas and greater microglial abundance in the PNS, while smaller species showed minimal or absence of these cells.

"This suggests that during evolution, PNS microglia played a critical role in neuronal development and maturation in large-bodied vertebrates. Their presence was likely preserved through natural selection, evolving into immune cells whose abundance correlates with vertebrate body size," Wu explained.

"PNS microglia are absent in small vertebrates like mice and rats, which have long served as primary model animals for scientific research. This may explain why these cells remained undetected until now," said Li, the study's corresponding author.

The research leveraged cutting-edge infrastructure, including Shenzhen's major synthetic biology and brain science facilities, as well as the facility for phenotypic and genetic analysis of model animals at the Kunming Institute of Zoology of the CAS.

The discovery may reshape understanding of various PNS related disorders. For instance, dysfunctions of these PNS microglia cells may contribute to congenital PNS defects during fetal development. It may provide new drug targets for treating PNS hereditary neurological diseases, said Li.

In PNS nerve injury or neurodegeneration, activation of PNS microglia may clear damaged tissues and promote neural regeneration. Besides, during viral infections, they may shield neurons from pathogens.

In pain regulation, PNS microglia may respond to the neuronal signals via releasing pain-causing molecules or secreting analgesic factors to modulate the pain symptoms in patients. This "double-edged sword" characteristic offers the possibility of precise intervention for pain management, Li added.

Top
BACK TO THE TOP
English
Copyright 1995 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
License for publishing multimedia online 0108263

Registration Number: 130349
FOLLOW US
 
主站蜘蛛池模板: 国产美女精品在线观看 | 欧美日韩不卡中文字幕在线 | 成人福利网址永久在线观看 | 国产麻豆精品一区二区 | 好大水好多好爽好硬好深视频 | 欧美黑人性大免费高清视频 | 成人网18免费软件大全 | 国产99久久精品一区二区 | 国产手机在线小视频免费观看 | 性激烈的欧美暴力三级视频 | 特极毛片 | 日韩黄色免费 | 亚洲欧美一区二区三区蜜芽 | 成熟热自由日本语亚洲人 | 午夜精品久久久久久久99 | 草操影院| 一级黄色绿像片 | 亚洲在线视频免费 | 91高清视频 | 成人午夜免费观看 | 久久精品国产400部免费看 | 久久精品亚洲欧美日韩久久 | 欧美日韩在线网站 | 在线观看日韩www视频免费 | 91精品国产自产91精品 | 亚洲国产aaa毛片无费看 | 久久88香港三级台湾三级中文 | 中国大陆高清aⅴ毛片 | 久久久久琪琪精品色 | 在线免费观看视频黄 | 极品色综合 | 色婷婷色婷婷 | 国产伦精品一区二区三区在线观看 | 九九精| 欧美毛片 | 中文字幕中出在线 | 丁香婷婷激情网 | 中国一级片免费 | 国产欧美日韩视频在线观看一区二区 | 亚洲黄色在线观看视频 | 国产精品国产高清国产专区 |