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Roche launches AVENIO ctDNA analysis kits for cancer research

chinadaily.com.cn | Updated: 2017-06-07 00:14
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Roche announced the global commercial launch of the AVENIO circulating tumor DNA (ctDNA) Analysis Kits, a portfolio of three next-generation sequencing (NGS) liquid biopsy assay kits for oncology research: the AVENIO ctDNA Targeted Kit, Expanded Kit and Surveillance Kit. The kits include all reagents, bioinformatics and software to make ctDNA testing accessible to all NGS laboratories.

"We are pleased to introduce these state-of-the-art AVENIO ctDNA Analysis Kits1,2,3that combine the convenience of liquid biopsy with the power of next generation sequencing," said Roland Diggelmann, Chief Executive Officer, Roche Diagnostics. "Roche believes the AVENIO ctDNA assays can help researchers around the world advance personalized oncology by enabling them to carry out their own testing."

The AVENIO ctDNA Analysis Kits are aligned with NCCN guidelines to support oncology research4. The kits detect all four mutation classes with high sensitivity4. With three different kits available, researchers can profile the genomic complexities of different cancer stages and tumor types, obtaining results in five days.

"As a cancer researcher, I see a tremendous advantage to using the AVENIO ctDNA Analysis Kits", said Peter Meldgaard, MD, PhD, Associate Professor of Oncology at Aarhus University in Denmark. "Cancer is a highly complex disease, so the ability to obtain a complete and accurate genomic profile of malignant tumors and monitor changes in tumor burden is invaluable."

About the AVENIO ctDNA Analysis Kits

The AVENIO ctDNA Analysis Kits are for research use only and not for use in diagnostic procedures.

Three NGS assay kits are available for oncology research:

Each kit includes all the reagents for DNA extraction, library preparation and target enrichment, as well as the software required to analyze sequencing data and generate reports. The AVENIO kits utilize Roche’s enhanced hybrid capture target enrichment techniques to analyse all four mutation classes - single nucleotide variant (SNV), insertion or deletion (indel), fusion and copy number variant (CNV) - in a single workflow. In addition, Roche’s proprietary error-suppression strategies enable the AVENIO ctDNA Analysis Kits to detect variant allele frequencies down to 0.1% while maintaining a low error rate down to 0.001%. The AVENIO product line of NGS solutions from Roche will include instruments and reagents that aim to make sequencing simple and accessible for everyday use.

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